Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 10/20 | 0.58 |
| ▸ | DCPS | Q96C86 | 6/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | LTK | P29376 | 1/20 | 0.51 |
| ▸ | GRK5 | P34947 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30482718 | 0.86 | DHFR (0.56) | DHFRDCPSADORA2AKCNH2 | |
| SCHEMBL12648993 | 0.85 | DHFR (0.55) | DHFRDCPSADORA2AKCNH2 | |
| SCHEMBL30482740 | 0.84 | ADORA2A (0.55) | DHFRDCPSMAP4K4ADORA2AKCNH2 | |
| SCHEMBL30482707 | 0.84 | DHFR (0.58) | DHFRDCPSMAP4K4KCNH2 | |
| SCHEMBL30482752 | 0.84 | DHFR (0.58) | DHFRDCPSADORA2AKCNH2 | |
| SCHEMBL30482758 | 0.84 | DHFR (0.58) | DHFRDCPSLCKCSF1RFGFR1 | |
| SCHEMBL21497083 | 0.84 | DCPS (0.47) | DHFRDCPSKCNH2 | |
| SCHEMBL30482755 | 0.83 | DHFR (0.61) | DHFRDCPSKDRKCNH2 | |
| SCHEMBL30482722 | 0.83 | DHFR (0.45) | DHFRDCPSKCNH2 | |
| SCHEMBL30482725 | 0.81 | DHFR (0.46) | DHFRDCPSADORA2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116354938-B | Preparation method and application of quinazoline derivatives and analogues thereof | 沈阳药科大学 | 2024-02-20 | — | — | CN | disclosed |
| CN-116354938-A | Preparation method and application of quinazoline derivatives and analogues thereof | 沈阳药科大学 | 2023-06-30 | — | — | CN | disclosed |
| EP-4100395-A1 | QUINAZOLINE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT OF CANCER | Trobio Therapeutics Pty Ltd (AU) | 2022-12-14 | — | — | EP | disclosed |