Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24877816 | 1.00 | ALOX15 (0.46) | ALOX15ADAMTS4ADAMTS5MAPK1CCR1 | |
| SCHEMBL30129118 | 0.90 | ALOX15 (0.39) | ALOX15CCR1LMNAFFAR4ALDH1A1 | |
| SCHEMBL24878004 | 0.90 | ALOX15 (0.39) | ALOX15CCR1LMNAFFAR4ALDH1A1 | |
| SCHEMBL24878419 | 0.89 | ALOX15 (0.44) | ALOX15MAPK1CCR1KMT2A | |
| SCHEMBL24877814 | 0.89 | CCR1 (0.48) | ALOX15ADAMTS5CCR1LMNAALDH1A1 | |
| SCHEMBL24877929 | 0.88 | LMNA (0.45) | ALOX15MAPK1CCR1LMNAALDH1A1 | |
| SCHEMBL24878546 | 0.85 | ALOX15 (0.41) | ALOX15ADAMTS5CCR1LMNATSHR | |
| SCHEMBL24878106 | 0.85 | CCR1 (0.48) | ALOX15CCR1 | |
| SCHEMBL24878548 | 0.85 | ALOX15 (0.47) | ALOX15CCR1LMNATSHRSMN1; SMN2 | |
| SCHEMBL30128852 | 0.85 | CCR1 (0.48) | ALOX15CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3886845-B1 | NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2, 3-DIOXYGENASE (IDO) INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-09-04 | — | — | EP | claimed |
| US-12264134-B2 | Substituted piperazine amide compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors | MERCK SHARP & DOHME LLC (US) | 2025-04-01 | — | — | US | disclosed |
| US-20230008022-A1 | NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2023-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230008022-A1 | NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | IDO1, IDO2, KYNU | ALOX15 633/4885ADAMTS4 1808/4885ADAMTS5 945/4885 |
| US-12264134-B2 | Substituted piperazine amide compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors | IDO1, IDO2, AADAC | ALOX15 859/4885ADAMTS4 1866/4885ADAMTS5 897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.