Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21412242 | 1.00 | MAPK1 (0.35) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL24248699 | 0.84 | HSP90AA1 (0.37) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL22658916 | 0.81 | PLAU (0.32) | MAPT | |
| SCHEMBL21412269 | 0.79 | PTGDR2 (0.37) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL30131949 | 0.79 | PTGDR2 (0.37) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL21412239 | 0.78 | DGAT1 (0.36) | — | |
| SCHEMBL30132046 | 0.78 | EGFR (0.37) | EGFR | |
| SCHEMBL30132080 | 0.78 | DGAT1 (0.36) | — | |
| SCHEMBL25885043 | 0.78 | EGFR (0.37) | EGFR | |
| SCHEMBL24253470 | 0.78 | HSP90AA1 (0.38) | MAPK1PIK3CAMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112203653-B | Compounds for the treatment of huntington's disease | PTC医疗公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-115768762-A | Compounds for the treatment of huntington's disease | PTC医疗公司 | 2023-03-07 | — | — | CN | disclosed |
| EP-4132923-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC Therapeutics, Inc. (US) | 2023-02-15 | — | — | EP | disclosed |