Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 3/20 | 0.31 |
| ▸ | OXTR | P30559 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24248699 | 0.82 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1MAPK1PIK3CAMAPK8 | |
| SCHEMBL22338096 | 0.80 | PDE4B (0.41) | HSP90AA1HSP90AB1MAPK1PIK3CAMAPK8 | |
| SCHEMBL24253574 | 0.79 | EGFR (0.35) | HSP90AA1HSP90AB1EGFRS1PR4PLAU | |
| SCHEMBL21412242 | 0.78 | MAPK1 (0.35) | HSP90AA1HSP90AB1MAPK1PIK3CAMAPK8 | |
| SCHEMBL30131990 | 0.78 | MAPK1 (0.35) | HSP90AA1HSP90AB1MAPK1PIK3CAMAPK8 | |
| SCHEMBL21412269 | 0.77 | PTGDR2 (0.37) | HSP90AA1HSP90AB1MAPK1PIK3CAMAPK8 | |
| SCHEMBL30131949 | 0.77 | PTGDR2 (0.37) | HSP90AA1HSP90AB1MAPK1PIK3CAMAPK8 | |
| SCHEMBL30275020 | 0.73 | CDK9 (0.40) | HSP90AA1HSP90AB1MAPK1PIK3CAMAPK8 | |
| SCHEMBL21410557 | 0.73 | KCNH2 (0.40) | — | |
| SCHEMBL25091840 | 0.71 | ALDH1A1 (0.40) | HSP90AA1HSP90AB1EGFRS1PR4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220048890-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. | 2022-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220048890-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | RBM17, SF3B1, SF3B5 | HSP90AA1 2009/4885HSP90AB1 1465/4885MAPK1 3807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.