Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 7/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | GRM6 | O15303 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29281266 | 0.93 | ALDH1A1 (0.41) | KDM4ETSHRSMN1; SMN2POLBKMT2A | |
| SCHEMBL30133135 | 0.85 | SMN1; SMN2 (0.38) | KDM4ETSHRSMN1; SMN2POLBKMT2A | |
| SCHEMBL30133129 | 0.84 | SMN1; SMN2 (0.39) | KDM4ETSHRSMN1; SMN2POLBKMT2A | |
| SCHEMBL30133087 | 0.80 | KDM4E (0.44) | KDM4ETSHRSMN1; SMN2POLBKMT2A | |
| SCHEMBL30133161 | 0.77 | MAPT (0.40) | KDM4ETSHRPOLBALDH1A1HSD17B10 | |
| SCHEMBL27238440 | 0.77 | MAPT (0.39) | KDM4EKMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL30133170 | 0.76 | PDE4B (0.38) | KDM4ESMN1; SMN2POLBKMT2AMEN1 | |
| SCHEMBL30133123 | 0.74 | ALDH1A1 (0.42) | KDM4ETSHRSMN1; SMN2POLBKMT2A | |
| SCHEMBL30133108 | 0.73 | MAPT (0.44) | KDM4ETSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL27238444 | 0.70 | GABRP (0.38) | KDM4ESMN1; SMN2KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4380940-A1 | NEW CYCLOPENTA-THIENO-DIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2024-06-12 | — | — | EP | disclosed |
| WO-2023012130-A1 | NEW CYCLOPENTA-THIENO-DIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. HOFFMANN-LA ROCHE AG (CH) | 2023-02-09 | — | — | WO | disclosed |