Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30376350 | 0.90 | LMNA (0.39) | HSD17B10CYP2D6TSHRSMN1; SMN2LMNA | |
| SCHEMBL30135848 | 0.84 | LMNA (0.39) | HSD17B10CYP2D6TSHRCYP3A4SMN1; SMN2 | |
| SCHEMBL22720703 | 0.79 | CYP11B2 (0.49) | HSD17B10CYP2D6TSHRCYP3A4GPR119 | |
| SCHEMBL30136007 | 0.79 | CRBN (0.48) | HSD17B10CYP2D6TSHRCYP3A4POLB | |
| SCHEMBL1448938 | 0.74 | GPR119 (0.41) | HSD17B10SMN1; SMN2LMNAPOLBOPRD1 | |
| SCHEMBL18153221 | 0.73 | CHRM1 (0.45) | LMNAALDH1A1CYP2C9GPR119 | |
| SCHEMBL30297575 | 0.73 | CYP3A4 (0.62) | HSD17B10CYP2D6TSHRCYP3A4SMN1; SMN2 | |
| SCHEMBL6986404 | 0.73 | POLB (0.48) | SMN1; SMN2LMNAPOLBMEN1KMT2A | |
| SCHEMBL1282238 | 0.72 | OPRM1 (0.39) | HSD17B10OPRD1OPRK1PANK3 | |
| SCHEMBL31580280 | 0.72 | RAB9A (0.33) | HSD17B10CYP2D6TSHRCYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157849-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | Uppthera, Inc. (KR) | 2023-04-05 | — | — | EP | disclosed |
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023018238-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |