Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 5/20 | 0.54 |
| ▸ | TACR2 | P21452 | 4/20 | 0.54 |
| ▸ | OXTR | P30559 | 1/20 | 0.53 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.52 |
| ▸ | EPS15 | P42566 | 1/20 | 0.51 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.49 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | NECTIN4 | Q96NY8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Kawaguchipeptin B SCHEMBL29884999 | 0.91 | KLKB1 (0.58) | TACR1TACR2OXTRKLKB1PDCD1 | |
| SCHEMBL29385568 | 0.82 | NECTIN4 (0.56) | KLKB1NECTIN4 | |
| SCHEMBL29934180 | 0.82 | ITGAV (0.50) | EPHA2ITGB3ITGAV | |
| SCHEMBL29420247 | 0.81 | KDM4A (0.56) | OXTRITGB3ITGAV | |
| Segetalin A SCHEMBL151176 | 0.81 | TACR1 (0.64) | TACR1TACR2OXTRHDAC3HDAC4 | |
| SCHEMBL29553179 | 0.80 | TACR1 (0.61) | TACR1TACR2HDAC3HDAC4HDAC1 | |
| SCHEMBL8568487 | 0.80 | OXTR (0.60) | TACR1TACR2OXTRPDCD1CD274 | |
| Desotamide SCHEMBL28783907 | 0.79 | OXTR (0.64) | OXTREPHA2NECTIN4 | |
| SCHEMBL31717765 | 0.79 | ROR1 (0.52) | TACR1TACR2HDAC3HDAC1HDAC8 | |
| SCHEMBL24724872 | 0.78 | PCSK9 (0.56) | OXTRKLKB1PDCD1CD274EPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115477611-B | MRGPRX2 antagonists for the treatment of pseudoallergy | 香港大学 | 2024-11-08 | — | — | CN | disclosed |
| US-20220401435-A1 | MRGPRX2 ANTAGONIST FOR THE TREATMENT OF PSEUDO ALLERGIC REACTIONS | THE UNIVERSITY OF HONG KONG | 2022-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220401435-A1 | MRGPRX2 ANTAGONIST FOR THE TREATMENT OF PSEUDO ALLERGIC REACTIONS | MRGPRX2, MRGPRX1, MRGPRX4 | TACR1 326/4885TACR2 698/4885OXTR 1354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.