SCHEMBL30140320

SCHEMBL30140320

C=CC(=O)N1CC[C@H](Oc2nc3c(Nc4ccc(CC(F)(F)F)c(Cl)c4)ncnc3cc2F)C1

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EGFR P00533 20/20 0.55
ERBB2 P04626 3/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30140434 0.89 GPR119 (0.47) EGFRERBB2
SCHEMBL30140120 0.86 EGFR (0.57) EGFRERBB2
SCHEMBL30140283 0.82 EGFR (0.61) EGFRERBB2
SCHEMBL23537721 0.81 EGFR (0.60) EGFRERBB2
SCHEMBL23537724 0.81 EGFR (0.60) EGFRERBB2
SCHEMBL30140382 0.80 EGFR (0.44) EGFRERBB2
SCHEMBL23570472 0.79 EGFR (0.69) EGFRERBB2
SCHEMBL30140394 0.78 EGFR (0.61) EGFRERBB2
SCHEMBL30140097 0.78 EGFR (0.59) EGFRERBB2
SCHEMBL30140356 0.77 EGFR (0.60) EGFRERBB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022266426-A1 6-(HETEROCYCLOALKYL-OXY)-QUINAZOLINE DERIVATIVES AND USES THEREOF BLACK DIAMOND THERAPEUTICS, INC. (US) 2022-12-22 WO disclosed