Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | GPR6 | P46095 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24758261 | 1.00 | P2RX7 (0.40) | P2RX7LMNAPTGS2HDAC1HDAC2 | |
| SCHEMBL24906460 | 0.86 | AKR1C3 (0.45) | P2RX7AKR1C3AKR1C2SCN10AALDH1A1 | |
| SCHEMBL24758348 | 0.85 | CNR1 (0.39) | P2RX7AKR1C3AKR1C2CNR1CNR2 | |
| SCHEMBL24757790 | 0.84 | AKR1C3 (0.35) | P2RX7PTGS2AKR1C3AKR1C2SCN10A | |
| SCHEMBL30141414 | 0.84 | AKR1C3 (0.35) | P2RX7PTGS2AKR1C3AKR1C2SCN10A | |
| SCHEMBL24906210 | 0.83 | P2RX7 (0.39) | P2RX7HDAC1HDAC2AKR1C3AKR1C2 | |
| SCHEMBL30141357 | 0.83 | SCN10A (0.43) | P2RX7AKR1C3AKR1C2SCN10ACNR1 | |
| SCHEMBL24906217 | 0.83 | SCN10A (0.43) | P2RX7AKR1C3AKR1C2SCN10ACNR1 | |
| SCHEMBL24906203 | 0.81 | P2RX7 (0.36) | P2RX7PTGS2TRPV1PTGS1CNR1 | |
| SCHEMBL24906358 | 0.80 | AKR1C3 (0.39) | AKR1C3AKR1C2SCN10ACNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | claimed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | claimed |
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | disclosed |