Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 10/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24758421 | 1.00 | SCN10A (0.42) | SCN10ANR3C1AKR1C3AKR1C2P2RX7 | |
| SCHEMBL24906499 | 0.88 | AKR1C3 (0.44) | SCN10ANR3C1AKR1C3AKR1C2P2RX7 | |
| SCHEMBL30141403 | 0.86 | NR3C1 (0.36) | SCN10ANR3C1AKR1C3AKR1C2CRHR1 | |
| SCHEMBL24906480 | 0.86 | NR3C1 (0.36) | SCN10ANR3C1AKR1C3AKR1C2CRHR1 | |
| SCHEMBL24906217 | 0.85 | SCN10A (0.43) | SCN10AAKR1C3AKR1C2P2RX7CNR1 | |
| SCHEMBL30141357 | 0.85 | SCN10A (0.43) | SCN10AAKR1C3AKR1C2P2RX7CNR1 | |
| SCHEMBL24758439 | 0.83 | SCN10A (0.46) | SCN10A | |
| SCHEMBL24757353 | 0.83 | SCN10A (0.48) | SCN10AAKR1C3AKR1C2 | |
| SCHEMBL24906294 | 0.81 | SCN10A (0.39) | SCN10ANR3C1AKR1C3AKR1C2 | |
| SCHEMBL24906339 | 0.81 | SCN10A (0.48) | SCN10AAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | disclosed |