Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 6/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 8/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24906480 | 1.00 | NR3C1 (0.36) | NR3C1AKR1C3AKR1C2SCN10ACRHR1 | |
| SCHEMBL24758439 | 0.87 | SCN10A (0.46) | SCN10A | |
| SCHEMBL30141517 | 0.86 | SCN10A (0.42) | NR3C1AKR1C3AKR1C2SCN10ACRHR1 | |
| SCHEMBL24757796 | 0.86 | NR3C1 (0.37) | NR3C1AKR1C3AKR1C2SCN10ACRHR1 | |
| SCHEMBL30141500 | 0.86 | NR3C1 (0.37) | NR3C1AKR1C3AKR1C2CRHR1CNR1 | |
| SCHEMBL24758421 | 0.86 | SCN10A (0.42) | NR3C1AKR1C3AKR1C2SCN10ACRHR1 | |
| SCHEMBL24758186 | 0.86 | NR3C1 (0.37) | NR3C1AKR1C3AKR1C2CRHR1CNR1 | |
| SCHEMBL24906499 | 0.83 | AKR1C3 (0.44) | NR3C1AKR1C3AKR1C2SCN10A | |
| SCHEMBL24758288 | 0.82 | SCN10A (0.45) | SCN10A | |
| SCHEMBL24906387 | 0.80 | CRHR1 (0.41) | NR3C1AKR1C3AKR1C2CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | claimed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | claimed |
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | disclosed |