Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.38 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.38 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | HTR1F | P30939 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24758422 | 1.00 | SCN10A (0.39) | SCN10ADDR1DDR2EPHB2NR3C1 | |
| SCHEMBL24906294 | 1.00 | SCN10A (0.39) | SCN10ADDR1DDR2EPHB2NR3C1 | |
| SCHEMBL24906533 | 0.84 | SCN10A (0.43) | SCN10ANR3C1AKR1C3AKR1C2 | |
| SCHEMBL24759017 | 0.83 | AKR1C3 (0.45) | DDR1DDR2EPHB2NR3C1ACKR3 | |
| SCHEMBL30107027 | 0.83 | AKR1C3 (0.45) | DDR1DDR2EPHB2NR3C1ACKR3 | |
| SCHEMBL30107028 | 0.83 | NR3C1 (0.38) | NR3C1AKR1C3AKR1C2 | |
| SCHEMBL24758290 | 0.83 | NR3C1 (0.38) | NR3C1AKR1C3AKR1C2 | |
| SCHEMBL30141370 | 0.82 | CRHR1 (0.41) | NR3C1AKR1C3AKR1C2 | |
| SCHEMBL24906387 | 0.82 | CRHR1 (0.41) | NR3C1AKR1C3AKR1C2 | |
| SCHEMBL24758421 | 0.81 | SCN10A (0.42) | SCN10ANR3C1AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | claimed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | claimed |
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | disclosed |