Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24758260 | 0.85 | HTR2A (0.33) | HTR2AHTR2CSLC6A4 | |
| SCHEMBL24758261 | 0.81 | P2RX7 (0.40) | P2RX7PTGS2PTGS1CNR1CNR2 | |
| SCHEMBL30141455 | 0.81 | P2RX7 (0.40) | P2RX7PTGS2PTGS1CNR1CNR2 | |
| SCHEMBL24906445 | 0.76 | CRHR1 (0.34) | P2RX7HTR2AHTR2CSLC6A4 | |
| SCHEMBL30141540 | 0.76 | CRHR1 (0.34) | P2RX7HTR2AHTR2CSLC6A4 | |
| SCHEMBL24906460 | 0.75 | AKR1C3 (0.45) | P2RX7 | |
| SCHEMBL24758348 | 0.74 | CNR1 (0.39) | P2RX7CNR1CNR2HTR2AHTR2C | |
| SCHEMBL24757790 | 0.73 | AKR1C3 (0.35) | P2RX7PTGS2PTGS1CNR1CNR2 | |
| SCHEMBL30141414 | 0.73 | AKR1C3 (0.35) | P2RX7PTGS2PTGS1CNR1CNR2 | |
| SCHEMBL24906217 | 0.72 | SCN10A (0.43) | P2RX7CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230025025-A1 | SUBSTITUTED PYRAZOLE AMIDES | GRUENENTHAL GMBH (DE) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230025025-A1 | SUBSTITUTED PYRAZOLE AMIDES | SCN8A, SCN1A, SCN7A | P2RX7 74/4885PTGS2 449/4885PTGS1 347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.