Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27243070 | 0.88 | LMNA (0.35) | LMNASLC34A1JAK2JAK1TYK2 | |
| SCHEMBL24757782 | 0.86 | LMNA (0.40) | LMNASLC34A1JAK2JAK1TYK2 | |
| SCHEMBL24758986 | 0.86 | CRHR1 (0.34) | CRHR1NR3C1HTR2AHTR2CSLC6A4 | |
| SCHEMBL24758185 | 0.85 | CRHR1 (0.33) | CNR2CRHR1NR3C1HTR2AHTR2C | |
| SCHEMBL24758333 | 0.84 | POLB (0.41) | LMNASLC34A1JAK2JAK1TYK2 | |
| SCHEMBL24906265 | 0.83 | ALDH1A1 (0.37) | LMNASLC34A1KMT2AKDM4EALDH1A1 | |
| SCHEMBL30975983 | 0.82 | LMNA (0.32) | LMNAKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL30976053 | 0.82 | LMNA (0.32) | LMNAKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL30975885 | 0.82 | LMNA (0.32) | LMNAKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL30976021 | 0.81 | LMNA (0.36) | LMNASLC34A1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | disclosed |