Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14340862 | 1.00 | HPGD (0.45) | HPGDNPC1ALDH1A1HTTRAB9A | |
| SCHEMBL29856941 | 0.79 | NPC1 (0.45) | NPC1ALDH1A1RAB9ADCUN1D1NOTUM | |
| SCHEMBL11683708 | 0.78 | ALDH1A1 (0.40) | HPGDNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL29891752 | 0.78 | PDE5A (0.51) | ALDH1A1CYP1A2CYP3A4DCUN1D1HSD17B10 | |
| SCHEMBL7591056 | 0.76 | PTGES (0.48) | — | |
| SCHEMBL28746022 | 0.75 | CYP1A2 (0.46) | ALDH1A1CYP1A2CYP3A4CYP2C19NPY5R | |
| SCHEMBL9296042 | 0.73 | PDE5A (0.57) | HPGDALDH1A1SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL1133436 | 0.73 | GAA (0.50) | HPGDNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1129657 | 0.72 | ALDH1A1 (0.39) | HPGDNPC1ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL674011 | 0.72 | NISCH (0.53) | HPGDNPC1ALDH1A1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022200523-A9 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19) | ALMAC DISCOVERY LIMITED (GB) | 2023-02-16 | — | — | WO | claimed |