Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9296042 | 0.82 | PDE5A (0.57) | PDE5AALDH1A1CYP1A2CASP1HSD17B10 | |
| SCHEMBL14340862 | 0.78 | HPGD (0.45) | ALDH1A1CYP1A2CYP3A4DCUN1D1HSD17B10 | |
| SCHEMBL30141985 | 0.78 | HPGD (0.45) | ALDH1A1CYP1A2CYP3A4DCUN1D1HSD17B10 | |
| SCHEMBL13851602 | 0.75 | KDM4E (0.64) | PDE5AAURKAFGFR1FGFR2MPO | |
| SCHEMBL3403152 | 0.75 | ADRA1A (0.54) | PDE5AAURKAALDH1A1DCUN1D1CCNB2 | |
| SCHEMBL29856941 | 0.75 | NPC1 (0.45) | ALDH1A1DCUN1D1CDK1GSK3AGAA | |
| SCHEMBL29360270 | 0.75 | ADRA1A (0.54) | PDE5AAURKAALDH1A1DCUN1D1CCNB2 | |
| SCHEMBL11683708 | 0.74 | ALDH1A1 (0.40) | ALDH1A1CYP1A2CYP3A4CYP2D6GAA | |
| SCHEMBL23736205 | 0.73 | SMPD3 (0.51) | PDE5AAURKAFGFR1FGFR2ALDH1A1 | |
| SCHEMBL7591056 | 0.72 | PTGES (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313295-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19) | Almac Discovery Limited (GB) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022200523-A1 | PHARMACEUTICALS COMPOUNDS AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19) | ALMAC DISCOVERY LIMITED (GB) | 2022-09-29 | — | — | WO | disclosed |