SCHEMBL30142767

SCHEMBL30142767

CCCCNc1ccc(C(=O)Nc2ncc(C#N)s2)c(-c2ccccc2)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ F2R P25116 2/20 0.40
▸ FNTA P49354 3/20 0.39
▸ FNTB P49356 3/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ CYP1A2 P05177 1/20 0.39
▸ CYP3A4 P08684 1/20 0.39
▸ CYP2C9 P11712 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ CYP2C19 P33261 1/20 0.39
▸ TDP1 Q9NUW8 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ POLQ O75417 2/20 0.38
▸ ABCB1 P08183 1/20 0.38
▸ ABCG2 Q9UNQ0 1/20 0.38
▸ SCN9A Q15858 1/20 0.37
▸ ALOX15 P16050 1/20 0.37
▸ KDR P35968 1/20 0.36
▸ STIM1 Q13586 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24074014 1.00 F2R (0.40) F2RFNTAFNTBKDM4EALDH1A1
SCHEMBL30142800 0.87 KDR (0.52) F2RPOLQALOX15KDRSTIM1
SCHEMBL24074003 0.87 KDR (0.52) F2RPOLQALOX15KDRSTIM1
SCHEMBL24074165 0.87 ALDH1A1 (0.48) F2RKDM4EALDH1A1LMNAHPGD
SCHEMBL30142748 0.86 PRSS12 (0.44) F2RPOLQALOX15KDR
SCHEMBL30142663 0.86 FBP1 (0.47) F2RFNTAFNTBALDH1A1LMNA
SCHEMBL24074004 0.86 FBP1 (0.47) F2RFNTAFNTBALDH1A1LMNA
SCHEMBL24074006 0.85 F2R (0.41) F2RKDM4EALDH1A1HPGDPOLQ
SCHEMBL30142807 0.85 F2R (0.41) F2RKDM4EALDH1A1HPGDPOLQ
SCHEMBL24074000 0.84 F2R (0.41) F2RFNTAFNTBALDH1A1POLQ

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2024-02-29 — — US disclosed
EP-4157888-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS Cullgen (Shanghai), Inc. (CN) 2023-04-05 — — EP disclosed
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2023-02-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS DDB1, DCLRE1A, MDM2 F2R 1930/4885FNTA 3132/4885FNTB 2086/4885
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS DDB1, DCLRE1A, MDM2 F2R 1930/4885FNTA 3132/4885FNTB 2086/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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