Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | OXTR | P30559 | 4/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.40 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3017469 | 0.93 | GBA1 (0.45) | RAB9ASMN1; SMN2GBA1MAPTLMNA | |
| SCHEMBL3016039 | 0.91 | MAPT (0.46) | RAB9ASMN1; SMN2MAPTOXTRAVPR1A | |
| SCHEMBL3002254 | 0.91 | SMN1; SMN2 (0.42) | RAB9ASMN1; SMN2MAPTOXTRAVPR1A | |
| SCHEMBL3006471 | 0.91 | RAB9A (0.41) | RAB9ASMN1; SMN2MAPTOXTRAVPR1A | |
| SCHEMBL3003810 | 0.91 | GBA1 (0.40) | RAB9ASMN1; SMN2GBA1MAPTALDH1A1 | |
| SCHEMBL3017174 | 0.91 | RAB9A (0.41) | RAB9ASMN1; SMN2MAPTOXTRAVPR1A | |
| SCHEMBL3008836 | 0.91 | KMT2A (0.40) | RAB9ASMN1; SMN2GBA1MAPTLMNA | |
| SCHEMBL3014690 | 0.90 | HSD11B1 (0.41) | RAB9ASMN1; SMN2MAPTOXTRAVPR1A | |
| SCHEMBL3017967 | 0.89 | GBA1 (0.42) | RAB9ASMN1; SMN2GBA1MAPTLMNA | |
| SCHEMBL3016941 | 0.89 | LIPE (0.44) | RAB9ASMN1; SMN2GBA1MAPTAVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722681-B2 | N-sulfonyl thiazolylpiperazine derivatives and related N-sulfonyl heterocyclic derivatives for the treatment of neuro degenerative diseases | NV REMYND (BE) | 2014-05-13 | — | — | US | disclosed |
| US-20100197703-A1 | N-SULFONYL THIAZOLYLPIPERAZINE DERIVATIVES AND RELATED N-SULFONYL HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV REMYND (BE) | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197703-A1 | N-SULFONYL THIAZOLYLPIPERAZINE DERIVATIVES AND RELATED N-SULFONYL HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | SMN1; SMN2, HTT, SNCA | RAB9A 2943/4885SMN1; SMN2 1/4885GBA1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.