Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS2 | Q96GW9 | 4/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | EIF4E | P06730 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30145335 | 0.91 | MARS2 (0.43) | MARS2JAK1CRHR1MAPTMAPK1 | |
| SCHEMBL20596512 | 0.88 | F10 (0.44) | MARS2JAK1CRHR1THRBKDM4E | |
| SCHEMBL20595852 | 0.86 | CYP11B1 (0.41) | PTGS1AKR1C3AKR1C2THRATHRB | |
| SCHEMBL20596490 | 0.82 | MARS2 (0.42) | MARS2JAK1CRHR1KDM4EALDH1A1 | |
| SCHEMBL20596077 | 0.81 | HSP90AA1 (0.39) | CRHR1PTGS1AKR1C3AKR1C2KDM4E | |
| SCHEMBL23419543 | 0.78 | LMNA (0.36) | CRHR1PTGS1AKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL20595596 | 0.77 | MARS2 (0.53) | MARS2JAK1CRHR1KDM4EALDH1A1 | |
| SCHEMBL20595912 | 0.77 | MAP2K4 (0.38) | PTGS1AKR1C3AKR1C2ALDH1A1TDP1 | |
| SCHEMBL20596625 | 0.75 | ABL1 (0.37) | KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL30145306 | 0.75 | ABL1 (0.37) | KDM4EALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11584744-B2 | Inhibitors of type 1 methionyl-tRNA synthetase and methods of using them | UNIVERSITY OF WASHINGTON (US) | 2023-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584744-B2 | Inhibitors of type 1 methionyl-tRNA synthetase and methods of using them | AARS1, EMG1, GARS1 | MARS2 12/4885JAK1 1522/4885CRHR1 1725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.