Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.58 |
| ▸ | KIF11 | P52732 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.44 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10120025 | 0.87 | HDAC8 (0.59) | HDAC8HDAC6KIF11ACHENPSR1 | |
| SCHEMBL1417591 | 0.82 | NPSR1 (0.69) | HDAC8HDAC6NPSR1ALDH1A1POLB | |
| SCHEMBL30137430 | 0.82 | NPSR1 (0.69) | HDAC8HDAC6NPSR1ALDH1A1POLB | |
| SCHEMBL18179392 | 0.81 | HDAC8 (0.53) | HDAC8HDAC6KIF11ACHENPSR1 | |
| SCHEMBL547853 | 0.81 | ACHE (0.55) | ACHENPSR1ALDH1A1 | |
| SCHEMBL5909363 | 0.80 | HDAC8 (0.83) | HDAC8HDAC6ALDH1A1POLBSLC7A5 | |
| SCHEMBL20285196 | 0.80 | HDAC8 (0.65) | HDAC8HDAC6KIF11ACHEALDH1A1 | |
| SCHEMBL2637669 | 0.79 | RXRA (0.54) | KIF11ACHEPOLB | |
| SCHEMBL29486118 | 0.79 | RXRA (0.54) | KIF11ACHEPOLB | |
| SCHEMBL548539 | 0.79 | ACHE (0.53) | KIF11ACHEALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115551864-A | Substituted tricyclic amides, analogs thereof, and methods of using the same | 爱彼特生物制药公司 | 2022-12-30 | — | — | CN | disclosed |