Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903546 | 0.84 | HPGDS (0.68) | NPC1RAB9APRMT5HPGDSALKBH2 | |
| SCHEMBL2850367 | 0.81 | ALKBH2 (0.72) | NPC1RAB9AHPGDSALKBH2MAPT | |
| SCHEMBL30882479 | 0.80 | HPGDS (0.49) | NPC1RAB9APRMT5HPGDSALKBH2 | |
| SCHEMBL3916180 | 0.80 | MAP4K4 (0.55) | NPC1RAB9APRMT5HPGDSALKBH2 | |
| SCHEMBL30882345 | 0.80 | HPGDS (0.51) | NPC1RAB9APRMT5HPGDSALKBH2 | |
| SCHEMBL30882559 | 0.78 | PRMT5 (0.47) | NPC1RAB9APRMT5HPGDSALKBH2 | |
| SCHEMBL18682731 | 0.77 | MKNK1 (0.55) | NPC1RAB9APRMT5HPGDSALKBH2 | |
| SCHEMBL1194458 | 0.75 | NPC1 (0.59) | NPC1RAB9APRMT5HPGDSALKBH2 | |
| SCHEMBL30882598 | 0.74 | RAB9A (0.43) | NPC1RAB9APRMT5HPGDSALKBH2 | |
| SCHEMBL23150226 | 0.74 | SMN1; SMN2 (0.48) | PRMT5SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115551864-A | Substituted tricyclic amides, analogs thereof, and methods of using the same | 爱彼特生物制药公司 | 2022-12-30 | — | — | CN | disclosed |