Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.41 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.41 |
| ▸ | TEAD2 | Q15562 | 2/20 | 0.41 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.41 |
| ▸ | CPT1A | P50416 | 1/20 | 0.41 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29301506 | 1.00 | HCAR3 (0.47) | HCAR3KDM4EHPGDALDH1A1TEAD1 | |
| SCHEMBL23535833 | 0.88 | HCAR3 (0.43) | HCAR3KDM4EHPGDHCAR2PTGER4 | |
| SCHEMBL29301503 | 0.88 | ALDH1A1 (0.41) | HCAR3KDM4EHPGDALDH1A1CPT2 | |
| SCHEMBL30041666 | 0.88 | HCAR3 (0.43) | HCAR3KDM4EHPGDHCAR2PTGER4 | |
| SCHEMBL28926100 | 0.85 | MAPT (0.42) | KDM4EHPGDALDH1A1 | |
| SCHEMBL30147699 | 0.85 | MAPT (0.42) | KDM4EHPGDALDH1A1 | |
| SCHEMBL30147656 | 0.85 | BRD4 (0.42) | KDM4ECPT2CPT1ACPT1BPTGER4 | |
| SCHEMBL25113848 | 0.80 | HCAR3 (0.50) | HCAR3KDM4EHPGDALDH1A1TEAD1 | |
| SCHEMBL23535727 | 0.78 | HCAR3 (0.55) | HCAR3KDM4EHPGDALDH1A1TEAD1 | |
| SCHEMBL30040739 | 0.78 | HCAR3 (0.55) | HCAR3KDM4EHPGDALDH1A1TEAD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149945-A1 | SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2023-03-22 | — | — | EP | disclosed |
| CN-115551864-A | Substituted tricyclic amides, analogs thereof, and methods of using the same | 爱彼特生物制药公司 | 2022-12-30 | — | — | CN | disclosed |