Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28926100 | 1.00 | MAPT (0.42) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30040757 | 0.89 | ALDH1A1 (0.40) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL23535685 | 0.89 | ALDH1A1 (0.40) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30147683 | 0.85 | HCAR3 (0.47) | KDM4EALDH1A1HPGD | |
| SCHEMBL29301506 | 0.85 | HCAR3 (0.47) | KDM4EALDH1A1HPGD | |
| SCHEMBL29301503 | 0.85 | ALDH1A1 (0.41) | MAPTKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL30147656 | 0.84 | BRD4 (0.42) | KDM4ETDP1 | |
| SCHEMBL18561359 | 0.80 | ADORA2A (0.47) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL14737303 | 0.79 | MAPT (0.50) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL20604896 | 0.79 | MAPT (0.44) | MAPTKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149945-A1 | SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2023-03-22 | — | — | EP | disclosed |
| CN-115551864-A | Substituted tricyclic amides, analogs thereof, and methods of using the same | 爱彼特生物制药公司 | 2022-12-30 | — | — | CN | disclosed |