SCHEMBL30152674

SCHEMBL30152674

COC(=O)c1cc(OC)c2oc(-c3cccc(C4(c5nncn5C)CC(C)C4)c3)nc2c1

nearest known ligand 0.50

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ CBLB Q13191 20/20 0.50
▸ CBL P22681 18/20 0.50
▸ CBLC Q9ULV8 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30792016 1.00 CBLB (0.50) CBLBCBLCBLC
SCHEMBL30792112 0.89 CBLB (0.51) CBLBCBLCBLC
SCHEMBL30152954 0.89 CBLB (0.51) CBLBCBLCBLC
SCHEMBL24819910 0.89 CBLB (0.51) CBLBCBLCBLC
SCHEMBL24819919 0.87 CBLB (0.50) CBLBCBL
SCHEMBL30153215 0.87 CBLB (0.50) CBLBCBL
SCHEMBL24818926 0.81 HPGD (0.38) —
SCHEMBL24818908 0.76 CBLB (0.39) CBLBCBL
SCHEMBL30153109 0.75 CBLB (0.53) CBLBCBLCBLC
SCHEMBL30153197 0.74 CBLB (0.54) CBLBCBLCBLC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4359381-A1 CBL-B MODULATORS AND USES THEREOF Nimbus Clio, Inc. (US) 2024-05-01 — — EP disclosed
WO-2022272248-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. (US) 2022-12-29 — — WO disclosed
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