Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 11/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24820656 | 0.89 | CETP (0.33) | HPGDSMN1; SMN2HSD17B10ESR2MAPT | |
| SCHEMBL24821953 | 0.86 | ESR1 (0.35) | HPGDESR1ESR2 | |
| SCHEMBL24818909 | 0.86 | ESR1 (0.33) | HPGDESR1ESR2 | |
| SCHEMBL30152674 | 0.81 | CBLB (0.50) | — | |
| SCHEMBL30792016 | 0.81 | CBLB (0.50) | — | |
| SCHEMBL24818910 | 0.80 | CD274 (0.35) | THRBKDM4EALDH1A1 | |
| SCHEMBL24818936 | 0.74 | CBL (0.32) | — | |
| SCHEMBL24818876 | 0.74 | CLK1 (0.43) | HPGDCLK1SMN1; SMN2HSD17B10GAA | |
| SCHEMBL24818935 | 0.74 | S1PR1 (0.34) | ESR1ESR2 | |
| SCHEMBL24819910 | 0.70 | CBLB (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |