Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBLB | Q13191 | 11/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ACP1 | P24666 | 1/20 | 0.32 |
| ▸ | C1R | P00736 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29189897 | 1.00 | CBLB (0.40) | CBLBCYP1A2CYP2D6USP2CYP3A4 | |
| SCHEMBL29190029 | 0.92 | CBLB (0.36) | CBLBP2RX7HSD11B1PIK3R1 | |
| SCHEMBL30152913 | 0.92 | CBLB (0.36) | CBLBP2RX7HSD11B1PIK3R1 | |
| SCHEMBL24819939 | 0.89 | CBLB (0.45) | CBLBPIK3R1 | |
| SCHEMBL29190107 | 0.82 | CBLB (0.31) | CBLB | |
| SCHEMBL30152945 | 0.82 | CBLB (0.31) | CBLB | |
| SCHEMBL30152749 | 0.81 | CBLB (0.43) | CBLBC1RHSD11B1PIK3R1 | |
| SCHEMBL24819869 | 0.81 | CBLB (0.43) | CBLBC1RHSD11B1PIK3R1 | |
| SCHEMBL30153218 | 0.78 | CETP (0.32) | CBLB | |
| SCHEMBL29190150 | 0.76 | C1R (0.42) | CBLBCYP1A2CYP2D6CYP3A4C1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359381-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-05-01 | — | — | EP | disclosed |
| CN-117858865-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |