Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | F11 | P03951 | 3/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25455442 | 0.78 | DGAT1 (0.43) | DGAT1F11F2PRSS1PRSS2 | |
| SCHEMBL21864818 | 0.76 | DGAT1 (0.41) | DGAT1F11F2PRSS1PRSS2 | |
| SCHEMBL30161251 | 0.76 | DGAT1 (0.41) | DGAT1F11F2PRSS1PRSS2 | |
| SCHEMBL1344397 | 0.74 | KDR (0.43) | F11EGFRPDGFRBKDRLIPG | |
| SCHEMBL2098884 | 0.72 | BACE1 (0.47) | DGAT1F11F2PRSS1PRSS2 | |
| SCHEMBL21047924 | 0.72 | LPL (0.44) | EGFRLIPGIDO1TDO2 | |
| SCHEMBL24744297 | 0.72 | EGFR (0.43) | EGFRLIPGIDO1TDO2 | |
| SCHEMBL31460801 | 0.72 | LPL (0.44) | EGFRLIPGIDO1TDO2 | |
| SCHEMBL28877892 | 0.71 | F11 (0.41) | DGAT1F11F2PRSS1PRSS2 | |
| SCHEMBL25454628 | 0.70 | DGAT1 (0.36) | DGAT1HIF1APRMT5WDR77FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4107146-A1 | GCN2 MODULATOR COMPOUNDS | Alesta Therapeutics BV (NL) | 2022-12-28 | — | — | EP | disclosed |