Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | STAT3 | P40763 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2028208 | 0.74 | ALDH1A1 (0.45) | HTTSMN1; SMN2STAT3GAAALDH1A1 | |
| SCHEMBL22806612 | 0.73 | ALDH1A1 (0.46) | HTTSMN1; SMN2STAT3GAAALDH1A1 | |
| SCHEMBL11731221 | 0.71 | ALDH1A1 (0.49) | HTTSMN1; SMN2STAT3GAAALDH1A1 | |
| SCHEMBL28214650 | 0.70 | ALDH1A1 (0.46) | HTTGAAALDH1A1HPGDKDM4E | |
| SCHEMBL8641950 | 0.70 | HRH1 (0.57) | MAPTHRH1 | |
| SCHEMBL28118305 | 0.69 | GAA (0.56) | HTTGAAALDH1A1HPGDKDM4E | |
| SCHEMBL3218532 | 0.68 | TLR8 (0.46) | ALPLTLR8 | |
| Hydrochloric Acid SCHEMBL28823670 | 0.67 | ALDH1A1 (0.41) | HTTSMN1; SMN2STAT3GAAALDH1A1 | |
| SCHEMBL29204419 | 0.67 | ALDH1A1 (0.43) | HTTGAAALDH1A1HPGDKDM4E | |
| SCHEMBL13344534 | 0.66 | PSMB5 (0.46) | HTTSMN1; SMN2STAT3GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4362978-A1 | IL4I1 INHIBITORS AND METHODS OF USE | Merck Sharp & Dohme LLC (US) | 2024-05-08 | — | — | EP | disclosed |
| WO-2023278222-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2023-01-05 | — | — | WO | disclosed |