Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.57 |
| ▸ | DRD1 | P21728 | 3/20 | 0.57 |
| ▸ | DRD4 | P21917 | 3/20 | 0.57 |
| ▸ | DRD5 | P21918 | 3/20 | 0.57 |
| ▸ | DRD3 | P35462 | 3/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | LTA4H | P09960 | 10/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ACP1 | P24666 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641286 | 0.84 | LTA4H (0.52) | LTA4HMEN1MAPTKMT2AACP1 | |
| SCHEMBL8639405 | 0.77 | HRH1 (0.67) | HRH1DRD1DRD4DRD5DRD3 | |
| SCHEMBL30367647 | 0.73 | TLR8 (0.63) | ACP1 | |
| SCHEMBL6575812 | 0.72 | MEN1 (0.86) | LTA4HMEN1MAPTKMT2A | |
| SCHEMBL31033194 | 0.72 | MEN1 (0.86) | LTA4HMEN1MAPTKMT2A | |
| SCHEMBL8773745 | 0.72 | HRH1 (1.00) | HRH1DRD1DRD4DRD5DRD3 | |
| SCHEMBL7138267 | 0.72 | LTA4H (0.66) | LTA4H | |
| SCHEMBL7141059 | 0.71 | LTA4H (1.00) | HRH1DRD1DRD4DRD5DRD3 | |
| SCHEMBL7133024 | 0.71 | LTA4H (0.75) | HRH1DRD1DRD4DRD5DRD3 | |
| SCHEMBL7133006 | 0.71 | LTA4H (0.64) | LTA4HMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |