Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 8/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31539789 | 0.88 | CYP4F2 (0.46) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL19204859 | 0.86 | CYP4F2 (0.47) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL767235 | 0.85 | CYP4F2 (0.44) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL21201478 | 0.85 | ALDH1A1 (0.48) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL19204864 | 0.85 | CYP4F2 (0.44) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL24610325 | 0.85 | ALDH1A1 (0.48) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL30279144 | 0.85 | ALDH1A1 (0.48) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL31162695 | 0.84 | ALDH1A1 (0.47) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL25073931 | 0.82 | CYP4F2 (0.42) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL806349 | 0.81 | RXRA (0.43) | LMNAALDH1A1POLBCYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377306-A1 | ROCK2 INHIBITORS AND USES THEREOF | President and Fellows of Harvard College (US) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |