Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29206642 | 1.00 | PIK3CD (0.36) | PIK3CDJAK2JAK1TYK2JAK3 | |
| SCHEMBL24826721 | 0.83 | PIK3CD (0.34) | PIK3CDJAK2JAK1TYK2JAK3 | |
| SCHEMBL24826722 | 0.77 | KDM4E (0.41) | PIK3CDJAK2JAK1TYK2JAK3 | |
| SCHEMBL22712403 | 0.75 | THRB (0.50) | PIK3CDJAK2JAK1TYK2JAK3 | |
| SCHEMBL29206645 | 0.74 | GPR119 (0.39) | ALDH1A1GPR119MEN1KMT2A | |
| SCHEMBL24824547 | 0.74 | GPR119 (0.39) | ALDH1A1GPR119MEN1KMT2A | |
| SCHEMBL30164912 | 0.74 | GPR119 (0.39) | ALDH1A1GPR119MEN1KMT2A | |
| SCHEMBL31320106 | 0.73 | EPHX2 (0.39) | PIK3CDJAK2JAK1TYK2JAK3 | |
| SCHEMBL31320104 | 0.73 | EPHX2 (0.39) | PIK3CDJAK2JAK1TYK2JAK3 | |
| SCHEMBL31380056 | 0.73 | EPHX2 (0.39) | PIK3CDJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022271612-A1 | HETEROCYCLIC EGFR INHIBITORS FOR USE IN THE TREATMENT OF CANCER | BLUEPRINT MEDICINES CORPORATION (US) | 2022-12-29 | — | — | WO | disclosed |