Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.51 |
| ▸ | RHEB | Q15382 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3033205 | 0.81 | HPGD (0.43) | KDM4EHSD17B10POLBALDH1A1 | |
| SCHEMBL27785580 | 0.76 | KDM4E (0.49) | KDM4EHSD17B10HTR4RHEBSMN1; SMN2 | |
| SCHEMBL3024598 | 0.73 | SMYD3 (0.44) | HTR4 | |
| SCHEMBL9452327 | 0.71 | RHEB (0.61) | KDM4EHSD17B10RHEBALDH1A1MEN1 | |
| SCHEMBL26686587 | 0.71 | KDM4E (0.55) | KDM4EHSD17B10RHEBALDH1A1MAPT | |
| SCHEMBL30633400 | 0.71 | KDM4E (0.55) | KDM4EHSD17B10RHEBALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL9452373 | 0.70 | RHEB (0.60) | KDM4EHSD17B10RHEBALDH1A1MEN1 | |
| SCHEMBL8441019 | 0.70 | SMN1; SMN2 (0.62) | KDM4EHSD17B10SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL3031984 | 0.70 | CYP1A2 (0.40) | KDM4EHSD17B10RHEBALDH1A1MAPT | |
| SCHEMBL3029318 | 0.70 | NGFR (0.42) | KDM4ERHEBSMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |
| US-20100216746-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-08-26 | — | — | US | disclosed |
| EP-2166856-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154271-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216746-A1 | CHEMICAL COMPOUNDS | SAMHD1, POLRMT, NUDT1 | KDM4E 1070/4885HSD17B10 761/4885HTR4 3561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.