Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 9/20 | 0.43 |
| ▸ | CA9 | Q16790 | 5/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
| ▸ | PRKCG | P05129 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | LYN | P07948 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28251675 | 0.79 | CYP1A2 (0.42) | CDK1CDK2EGFRLCKSRC | |
| SCHEMBL2429098 | 0.78 | CYP1A2 (0.41) | EGFRFGFR1CLK4MAPK1MAPT | |
| Hydrochloric Acid SCHEMBL7659960 | 0.78 | CYP1A2 (0.41) | CDK1CDK2EGFRLCKSRC | |
| SCHEMBL3014789 | 0.74 | LMNA (0.40) | SYKGSK3BCLK4MEN1KMT2A | |
| SCHEMBL4409381 | 0.74 | NPC1 (0.41) | EGFRMAPK9CSNK2A1MAPK1MAPT | |
| Benzenesulfonamide SCHEMBL3122181 | 0.72 | CA1 (0.44) | CA2CA9CA4CLK4MAPK1 | |
| SCHEMBL3016796 | 0.70 | ROCK1 (0.48) | CA9CDK1CDK2CDK5ROCK1 | |
| SCHEMBL27491044 | 0.70 | HAVCR2 (0.37) | EGFRSRCMAPTMEN1KMT2A | |
| SCHEMBL28197754 | 0.69 | HDAC1 (0.36) | MEN1KMT2A | |
| SCHEMBL27397516 | 0.68 | ROCK1 (0.55) | CA2CA9CDK1CDK2CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100204187-A1 | Purine Derivatives | PALAU PHARMA, S.A. (ES) | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204187-A1 | Purine Derivatives | JAK3, JAK1, JAK2 | CA2 4678/4885CA9 4761/4885CA4 4752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.