Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 2/20 | 0.39 |
| ▸ | EDNRA | P25101 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12164465 | 1.00 | PYCR1 (0.49) | PYCR1GABRA1GABRB2EDNRBEDNRA | |
| SCHEMBL15905723 | 0.82 | PYCR1 (0.46) | PYCR1EDNRBEDNRACA1CA2 | |
| SCHEMBL8365116 | 0.81 | SMN1; SMN2 (0.41) | PYCR1GABRA1GABRB2EDNRBEDNRA | |
| SCHEMBL29676673 | 0.81 | PYCR1 (0.49) | PYCR1CA1CA2MEN1MAPT | |
| SCHEMBL307129 | 0.81 | PYCR1 (0.49) | PYCR1CA1CA2MEN1MAPT | |
| SCHEMBL7787482 | 0.80 | GABRA1 (0.44) | PYCR1GABRA1GABRB2EDNRBEDNRA | |
| SCHEMBL8587112 | 0.79 | PYCR1 (0.47) | PYCR1CA1CA2MEN1MAPT | |
| SCHEMBL30352488 | 0.79 | PYCR1 (0.47) | PYCR1LMNAHPGDMEN1MAPT | |
| SCHEMBL29418547 | 0.79 | PYCR1 (0.47) | PYCR1CA1CA2MEN1MAPT | |
| SCHEMBL375783 | 0.79 | PYCR1 (0.47) | PYCR1CA1CA2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126825-A1 | AMINOCYCLOBUTANES AS MONOACYLGLYCEROL LIPASE MODULATORS | Janssen Pharmaceutica NV (BE) | 2023-02-08 | — | — | EP | disclosed |