Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CMA1 | P23946 | 3/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24834513 | 1.00 | ALOX15 (0.56) | ALOX15TSHRCMA1PTGDR2MAPT | |
| SCHEMBL30169756 | 0.87 | CYP2C19 (0.51) | ALOX15TSHRCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL24834484 | 0.87 | ADORA2A (0.41) | ALOX15MAPTAKR1B1 | |
| SCHEMBL24834837 | 0.83 | ALOX15 (0.60) | ALOX15TSHRCMA1PTGDR2MAPT | |
| SCHEMBL24834534 | 0.80 | NLRP3 (0.51) | ALOX15TSHRAKR1B1HTT | |
| SCHEMBL24834578 | 0.80 | ALOX15 (0.56) | ALOX15TSHRCMA1PTGDR2MAPT | |
| SCHEMBL30169678 | 0.80 | NLRP3 (0.50) | ALOX15RAB9A | |
| SCHEMBL24834486 | 0.80 | NLRP3 (0.50) | ALOX15RAB9A | |
| SCHEMBL24834533 | 0.78 | ALOX15 (0.54) | ALOX15TSHRCMA1PTGDR2MAPT | |
| SCHEMBL24076918 | 0.76 | ALOX15 (0.65) | ALOX15TSHRCMA1PTGDR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4363418-A1 | 5-OXO-PYRIDO[2,3-D]PYRIDAZIN-6(5H)-YL ACETAMIDES | JANSSEN Pharmaceutica NV (BE) | 2024-05-08 | — | — | EP | disclosed |
| CN-117545757-A | 5-oxo-pyrido [2,3-d ] pyridazin-6 (5H) -ylacetamides | 詹森药业有限公司 | 2024-02-09 | — | — | CN | disclosed |
| WO-2023275230-A1 | 5-OXO-PYRIDO[2,3-D]PYRIDAZIN-6(5H)-YL ACETAMIDES | JANSSEN PHARMACEUTICA NV (BE) | 2023-01-05 | — | — | WO | disclosed |