Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Benzenesulfonamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 15/20 | 0.76 |
| ▸ | CA2 | P00918 | 15/20 | 0.76 |
| ▸ | CA12 | O43570 | 13/20 | 0.76 |
| ▸ | CA9 | Q16790 | 12/20 | 0.76 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.76 |
| ▸ | CA3 | P07451 | 1/20 | 0.76 |
| ▸ | CA4 | P22748 | 1/20 | 0.76 |
| ▸ | CA6 | P23280 | 1/20 | 0.76 |
| ▸ | CA5A | P35218 | 1/20 | 0.76 |
| ▸ | CA7 | P43166 | 1/20 | 0.76 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.76 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.76 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.76 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.53 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzenesulfonamide SCHEMBL27508743 | 1.00 | CA1 (0.76) | CA1CA2CA12CA9CA14 | |
| Benzenesulfonamide SCHEMBL27674479 | 0.90 | CA2 (0.84) | CA1CA2CA12CA9CA14 | |
| Benzenesulfonamide SCHEMBL29289462 | 0.90 | CA2 (0.84) | CA1CA2CA12CA9CA14 | |
| Benzenesulfonamide SCHEMBL29547253 | 0.88 | CA2 (0.80) | CA1CA2CA12CA9CA14 | |
| Benzenesulfonamide SCHEMBL27473289 | 0.88 | CA2 (0.80) | CA1CA2CA12CA9CA14 | |
| Benzenesulfonamide SCHEMBL28194516 | 0.87 | CA2 (0.89) | CA1CA2CA12CA9CA14 | |
| Benzenesulfonamide SCHEMBL1332409 | 0.87 | CA2 (1.00) | CA1CA2CA12CA9CA14 | |
| Benzenesulfonamide SCHEMBL6868390 | 0.87 | CA2 (1.00) | CA1CA2CA12CA9CA14 | |
| SCHEMBL19479299 | 0.87 | CA2 (1.00) | CA1CA2CA12CA9CA14 | |
| Benzenesulfonamide SCHEMBL29825137 | 0.87 | CA2 (1.00) | CA1CA2CA12CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115745896-B | JAK2 kinase selective inhibitor and preparation method and application thereof | 合肥医工医药股份有限公司 | 2024-08-06 | — | — | CN | disclosed |
| CN-115745896-A | JAK2 kinase selective inhibitor and preparation method and application thereof | 合肥医工医药股份有限公司 | 2023-03-07 | — | — | CN | disclosed |