Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | ATP4A | P20648 | 1/20 | 0.46 |
| ▸ | ATP4B | P51164 | 1/20 | 0.46 |
| ▸ | PHGDH | O43175 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28702412 | 0.81 | MEN1 (0.49) | ALDH1A1ATP4AATP4BKMT2AMAPT | |
| SCHEMBL11781024 | 0.74 | ALDH1A1 (0.51) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL6017146 | 0.74 | ALDH1A1 (0.55) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL9830681 | 0.72 | ALDH1A1 (0.49) | ALDH1A1ATP4AATP4BKMT2AMAPT | |
| SCHEMBL15646308 | 0.70 | ALDH1A1 (0.50) | ALDH1A1ATP4AATP4BKMT2AMAPT | |
| SCHEMBL27712566 | 0.70 | MAPT (0.58) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL11705681 | 0.68 | ALDH1A1 (0.52) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL7056572 | 0.68 | ALDH1A1 (0.52) | ALDH1A1PHGDHKMT2AMAPTMEN1 | |
| SCHEMBL9093997 | 0.68 | ALDH1A1 (0.56) | ALDH1A1ATP4AATP4BKMT2AMAPT | |
| SCHEMBL3026770 | 0.68 | SLC22A6 (0.41) | ALDH1A1PHGDHKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9316633-B2 | Methods for identifying inhibitors of solute transporters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-04-19 | — | — | US | disclosed |
| US-8394788-B2 | Phenylsulfoxyoxazole compound inhibitors of urea transporters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-03-12 | — | — | US | disclosed |
| US-8394788-B2 | Phenylsulfoxyoxazole compound inhibitors of urea transporters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-03-12 | — | — | US | disclosed |
| US-20100305105-A1 | PHENYLSULFOXYOXAZOLE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100305105-A1 | PHENYLSULFOXYOXAZOLE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100190796-A1 | METHODS FOR IDENTIFYING INHIBITORS OF SOLUTE TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-07-29 | — | — | US | disclosed |
| WO-2008061248-A3 | PHENYLSULFOXYOXAZOLE COMPOUND INHIBITORS OF UREA TRANSPORTERS | VERKMAN ALAN S (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008067196-A2 | METHODS FOR IDENTIFYING INHIBITORS OF SOLUTE TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-06-05 | — | — | WO | disclosed |
| WO-2008061248-A2 | PHENYLSULFOXYOXAZOLE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008061248-A2 | PHENYLSULFOXYOXAZOLE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190796-A1 | METHODS FOR IDENTIFYING INHIBITORS OF SOLUTE TRANSPORTERS | SLC2A1, SLC2A3, SLC2A8 | ALDH1A1 3404/4885ATP4A 218/4885ATP4B 276/4885 |
| US-20100305105-A1 | PHENYLSULFOXYOXAZOLE COMPOUND INHIBITORS OF UREA TRANSPORTERS | SLC14A1, SLCO4C1, SLCO2B1 | ALDH1A1 2350/4885ATP4A 230/4885ATP4B 349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.