Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30867869 | 0.90 | HDAC1 (0.34) | NR1H2HDAC1NR1H3GPR119HSD11B1 | |
| SCHEMBL30867873 | 0.89 | HDAC1 (0.39) | NR1H2HDAC1USP30ARNR1H3 | |
| SCHEMBL30867686 | 0.85 | HSD11B1 (0.35) | HDAC1GPR119HSD11B1 | |
| SCHEMBL30911135 | 0.81 | GPR119 (0.46) | USP30GPR119PIK3CA | |
| SCHEMBL30911167 | 0.81 | GPR119 (0.46) | USP30GPR119PIK3CA | |
| SCHEMBL30867805 | 0.81 | NR1H2 (0.33) | NR1H2HDAC1USP30ARNR1H3 | |
| SCHEMBL30172436 | 0.75 | NTRK1 (0.44) | NTRK1 | |
| SCHEMBL38653141 | 0.75 | HDAC1 (0.41) | NR1H2HDAC1UCHL1GPR119PIK3CA | |
| SCHEMBL38653820 | 0.74 | ACACB (0.36) | GPR119 | |
| SCHEMBL30867765 | 0.71 | GPR119 (0.51) | GPR119PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598917-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076674-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |