Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24992536 | 1.00 | HPGD (0.56) | HPGDADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL23089463 | 0.84 | HPGD (0.51) | HPGDADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL23089187 | 0.79 | HPGD (0.57) | HPGDADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL1684582 | 0.79 | HPGD (0.57) | HPGDADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL28876641 | 0.79 | HPGD (0.57) | HPGDADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL29424937 | 0.79 | LMNA (0.51) | ADORA2BADORA2AADORA1ADORA3KMT2A | |
| SCHEMBL1268686 | 0.79 | LMNA (0.51) | ADORA2BADORA2AADORA1ADORA3KMT2A | |
| SCHEMBL24992544 | 0.78 | ADORA2B (0.46) | HPGDADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL24992537 | 0.78 | ADORA2B (0.46) | HPGDADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL30172985 | 0.78 | ADORA2B (0.46) | HPGDADORA2BADORA2AADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4380565-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| CN-117915912-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2024-04-19 | — | — | CN | disclosed |
| WO-2023015199-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2023-02-09 | — | — | WO | disclosed |