Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.35 |
| ▸ | HTR3B | O95264 | 2/20 | 0.35 |
| ▸ | HTR3A | P46098 | 2/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24992649 | 1.00 | CHRNB2 (0.37) | CHRNB2CHRNA4HTR3EHTR3BHTR3A | |
| SCHEMBL20571883 | 0.73 | HTR2A (0.37) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL1066754 | 0.73 | NOTUM (0.42) | CHRNB2CHRNA4HTR3EHTR3BHTR3A | |
| SCHEMBL20703940 | 0.71 | MAOA (0.46) | CHRNB2CHRNA4HTR3EHTR3BHTR3A | |
| SCHEMBL20572197 | 0.70 | NOTUM (0.36) | CHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL29363884 | 0.70 | NOTUM (0.36) | CHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL17624110 | 0.70 | ABHD6 (0.43) | CHRNB2CHRNA4HTR3EHTR3BHTR3A | |
| SCHEMBL1040520 | 0.68 | CYP2C9 (0.47) | CHRNB2CHRNA4HTR3EHTR3BHTR3A | |
| SCHEMBL18995627 | 0.64 | NOTUM (0.35) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL2849413 | 0.63 | MAOA (0.53) | HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4380565-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| CN-117915912-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2024-04-19 | — | — | CN | disclosed |
| WO-2023015199-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2023-02-09 | — | — | WO | disclosed |