Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.57 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CKS1B | P61024 | 2/20 | 0.49 |
| ▸ | SKP1 | P63208 | 2/20 | 0.49 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25279682 | 1.00 | GPR119 (0.57) | GPR119PTPN11ACHEMAPTCKS1B | |
| SCHEMBL30892122 | 0.87 | PTPN11 (0.60) | GPR119PTPN11ACHEMAPTCKS1B | |
| SCHEMBL20234570 | 0.87 | PTPN11 (0.60) | GPR119PTPN11ACHEMAPTCKS1B | |
| SCHEMBL31229071 | 0.86 | GPR119 (0.56) | GPR119PTPN11ACHEMAPTCKS1B | |
| SCHEMBL25278635 | 0.86 | GPR119 (0.56) | GPR119PTPN11ACHEMAPTCKS1B | |
| SCHEMBL25239083 | 0.86 | ALDH1A1 (0.62) | GPR119PTPN11ACHEMAPTCKS1B | |
| SCHEMBL30173624 | 0.86 | ALDH1A1 (0.62) | GPR119PTPN11ACHEMAPTCKS1B | |
| SCHEMBL25274946 | 0.85 | GPR119 (0.55) | GPR119PTPN11ACHEMAPTCKS1B | |
| SCHEMBL30166221 | 0.85 | GPR119 (0.55) | GPR119PTPN11ACHEMAPTCKS1B | |
| SCHEMBL25233306 | 0.85 | GPR119 (0.54) | GPR119PTPN11ACHEMAPTCKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115697972-B | Receptor-interacting protein 1 inhibitors including piperazine heterocyclic amide urea | 维泰瑞隆有限公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-115697972-A | Receptor-interacting protein 1 inhibitors comprising piperazine heterocyclic amide ureas | 维泰瑞隆有限公司 | 2023-02-03 | — | — | CN | disclosed |