Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CKS1B | P61024 | 2/20 | 0.49 |
| ▸ | SKP1 | P63208 | 2/20 | 0.49 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.49 |
| ▸ | SMO | Q99835 | 1/20 | 0.46 |
| ▸ | CCNK | O75909 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CCND3 | P30281 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30173624 | 1.00 | ALDH1A1 (0.62) | ALDH1A1PTPN11GPR119ACHEMAPT | |
| SCHEMBL20234570 | 0.87 | PTPN11 (0.60) | ALDH1A1PTPN11GPR119ACHEMAPT | |
| SCHEMBL30892122 | 0.87 | PTPN11 (0.60) | ALDH1A1PTPN11GPR119ACHEMAPT | |
| SCHEMBL25279682 | 0.86 | GPR119 (0.57) | ALDH1A1PTPN11GPR119ACHEMAPT | |
| SCHEMBL30173654 | 0.86 | GPR119 (0.57) | ALDH1A1PTPN11GPR119ACHEMAPT | |
| SCHEMBL30173612 | 0.85 | GPR119 (0.48) | ALDH1A1PTPN11GPR119ACHEMAPT | |
| SCHEMBL25230495 | 0.85 | GPR119 (0.48) | ALDH1A1PTPN11GPR119ACHEMAPT | |
| SCHEMBL25263333 | 0.85 | PTPN11 (0.53) | PTPN11GPR119ACHEMAPTCKS1B | |
| SCHEMBL25234802 | 0.83 | PTPN11 (0.45) | ALDH1A1PTPN11GPR119ACHEMAPT | |
| SCHEMBL21159159 | 0.81 | GPR119 (0.60) | ALDH1A1PTPN11GPR119ACHEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12612388-B2 | Receptor-interacting protein 1 inhibitors including piperazine heterocyclic amide ureas | Sironax Ltd. (KY) | 2026-04-28 | — | — | US | disclosed |
| US-20230192662-A1 | Receptor-Interacting Protein 1 Inhibitors Including Piperazine Heterocyclic Amide Ureas | Sironax Ltd. (KY) | 2023-06-22 | — | — | US | disclosed |
| CN-115697972-A | Receptor-interacting protein 1 inhibitors comprising piperazine heterocyclic amide ureas | 维泰瑞隆有限公司 | 2023-02-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192662-A1 | Receptor-Interacting Protein 1 Inhibitors Including Piperazine Heterocyclic Amide Ureas | RIPK1, RIPK3, RIPK4 | ALDH1A1 4200/4885PTPN11 2182/4885GPR119 1258/4885 |
| US-12612388-B2 | Receptor-interacting protein 1 inhibitors including piperazine heterocyclic amide ureas | NCOR1, NCOR2, SUCNR1 | ALDH1A1 4498/4885PTPN11 1250/4885GPR119 568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.