Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30209660 | 0.86 | TSHR (0.38) | KDM4CKDM4EALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL29034775 | 0.84 | KDM4E (0.38) | KDM4EALDH1A1TDP1SMN1; SMN2POLB | |
| SCHEMBL1304161 | 0.84 | SMN1; SMN2 (0.41) | KDM4CKDM4EALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL6052434 | 0.80 | KDM4E (0.41) | KDM4EALDH1A1TDP1SMN1; SMN2POLB | |
| SCHEMBL4716984 | 0.78 | AGTR1 (0.42) | KDM4EALDH1A1TDP1SMN1; SMN2POLB | |
| SCHEMBL23985317 | 0.76 | CYP17A1 (0.35) | KDM4CPOLBTSHRCYP1A2 | |
| SCHEMBL3580133 | 0.76 | LMNA (0.54) | KDM4EALDH1A1TDP1SMN1; SMN2POLB | |
| SCHEMBL24770317 | 0.76 | HPGD (0.36) | KDM4CALDH1A1SMN1; SMN2POLBMEN1 | |
| SCHEMBL29224308 | 0.75 | ALDH1A1 (0.42) | KDM4EALDH1A1TDP1SMN1; SMN2MAPT | |
| SCHEMBL17438003 | 0.74 | KDM4E (0.40) | KDM4EALDH1A1TDP1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4408530-A1 | BENZIMIDAZOLES AS MODULATORS OF IL-17 | Janssen Pharmaceutica NV (BE) | 2024-08-07 | — | — | EP | disclosed |
| WO-2023049888-A1 | BENZIMIDAZOLES AS MODULATORS OF IL-17 | JANSSEN PHARMACEUTICA NV (BE) | 2023-03-30 | — | — | WO | disclosed |
| CN-115867348-A | Imidazopyrimidines as IL-17 modulators | 詹森药业有限公司 | 2023-03-28 | — | — | CN | disclosed |
| EP-4143193-A1 | IMIDAZOPYRIMIDINES AS MODULATORS OF IL-17 | JANSSEN Pharmaceutica NV (BE) | 2023-03-08 | — | — | EP | disclosed |