Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.42 |
| ▸ | EDNRB | P24530 | 2/20 | 0.42 |
| ▸ | EDNRA | P25101 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23886835 | 1.00 | HTR3A (0.42) | HTR3AEDNRBEDNRAMEN1NPC1 | |
| SCHEMBL30337916 | 0.94 | HTR3A (0.42) | HTR3AEDNRBEDNRAMEN1NPC1 | |
| SCHEMBL30176263 | 0.94 | HTR3A (0.42) | HTR3AEDNRBEDNRAMEN1NPC1 | |
| SCHEMBL23886750 | 0.94 | HTR3A (0.42) | HTR3AEDNRBEDNRAMEN1NPC1 | |
| SCHEMBL30176391 | 0.89 | PLA2G2A (0.40) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL23887040 | 0.89 | PLA2G2A (0.40) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL30176393 | 0.89 | PLA2G2A (0.40) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL28995402 | 0.85 | EDNRB (0.40) | HTR3AEDNRBEDNRAMEN1NPC1 | |
| SCHEMBL28995426 | 0.84 | PLA2G2A (0.46) | EDNRBEDNRAFFAR1LTB4RLTB4R2 | |
| SCHEMBL23886720 | 0.82 | PLA2G2A (0.45) | HTR3AEDNRBEDNRAMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916749-A | Substituted 5-hydroxyindole compounds as alpha-1 antitrypsin modulators | 弗特克斯药品有限公司 | 2023-04-04 | — | — | CN | disclosed |
| EP-4126817-A1 | SUBSTITUTED 5-HYDROXYINDOLE COMPOUNDS AS MODULATORS OF ALPHA-1 ANTITRYPSIN | Vertex Pharmaceuticals Incorporated (US) | 2023-02-08 | — | — | EP | disclosed |