Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23887040 | 1.00 | PLA2G2A (0.40) | PLA2G2AS1PR3GAAGFERHPGD | |
| SCHEMBL30176391 | 1.00 | PLA2G2A (0.40) | PLA2G2AS1PR3GAAGFERHPGD | |
| SCHEMBL30176346 | 0.89 | HTR3A (0.42) | PLA2G2ASMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL23886835 | 0.89 | HTR3A (0.42) | PLA2G2ASMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL23898352 | 0.87 | GAA (0.45) | PLA2G2AS1PR3GAAGFERHPGD | |
| SCHEMBL23886750 | 0.83 | HTR3A (0.42) | PLA2G2AMEN1KMT2AMAPT | |
| SCHEMBL30176263 | 0.83 | HTR3A (0.42) | PLA2G2AMEN1KMT2AMAPT | |
| SCHEMBL30337916 | 0.83 | HTR3A (0.42) | PLA2G2AMEN1KMT2AMAPT | |
| SCHEMBL23898350 | 0.78 | PLA2G2A (0.45) | PLA2G2AS1PR3GAAGFERHPGD | |
| SCHEMBL23898349 | 0.76 | KMT2A (0.43) | GAAGFERHPGDLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126817-A1 | SUBSTITUTED 5-HYDROXYINDOLE COMPOUNDS AS MODULATORS OF ALPHA-1 ANTITRYPSIN | Vertex Pharmaceuticals Incorporated (US) | 2023-02-08 | — | — | EP | disclosed |