Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.54 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 5/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12356941 | 1.00 | AXL (0.61) | AXLPDGFRBPDGFRALOXL2KDM4E | |
| SCHEMBL10435155 | 0.86 | AXL (0.57) | AXLPDGFRBPDGFRALOXL2KDM4E | |
| SCHEMBL4568032 | 0.86 | CA2 (0.51) | AXLPDGFRBPDGFRAKDM4EMAPT | |
| SCHEMBL8760755 | 0.83 | LOXL2 (0.56) | AXLPDGFRBPDGFRALOXL2KDM4E | |
| SCHEMBL8761856 | 0.81 | AXL (0.56) | AXLPDGFRBPDGFRALOXL2KDM4E | |
| SCHEMBL6859892 | 0.81 | PTGS2 (0.57) | AXLPDGFRBPDGFRAKDM4EMAPT | |
| SCHEMBL12180321 | 0.80 | KDM4E (0.50) | AXLKDM4EMAPTMEN1KMT2A | |
| SCHEMBL24075737 | 0.79 | HTR1B (0.42) | PDGFRBPDGFRAKDM4EMAPTNPC1 | |
| SCHEMBL28391028 | 0.79 | KDM4E (0.57) | AXLPDGFRBPDGFRALOXL2KDM4E | |
| SCHEMBL16756014 | 0.79 | AXL (0.53) | AXLPDGFRBPDGFRALOXL2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126817-A1 | SUBSTITUTED 5-HYDROXYINDOLE COMPOUNDS AS MODULATORS OF ALPHA-1 ANTITRYPSIN | Vertex Pharmaceuticals Incorporated (US) | 2023-02-08 | — | — | EP | disclosed |