Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30177254 | 0.88 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAPOLBOPRD1OPRK1 | |
| SCHEMBL30177282 | 0.85 | LMNA (0.50) | SMN1; SMN2LMNAPOLBOPRD1OPRK1 | |
| SCHEMBL30225407 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAPOLBOPRD1OPRK1 | |
| SCHEMBL5156110 | 0.80 | LMNA (0.59) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL30177238 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAPOLBOPRD1OPRK1 | |
| SCHEMBL21384398 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAPOLBOPRD1OPRK1 | |
| SCHEMBL31693845 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAPOLBOPRD1OPRK1 | |
| SCHEMBL30013395 | 0.79 | LMNA (0.48) | SMN1; SMN2LMNAPOLBOPRD1OPRK1 | |
| SCHEMBL29387500 | 0.79 | LMNA (0.49) | SMN1; SMN2LMNAPOLBOPRD1OPRK1 | |
| SCHEMBL30002152 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAPOLBOPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126852-A1 | AZASPIROCYCLES AS MONOACYLGLYCEROL LIPASE MODULATORS | Janssen Pharmaceutica NV (BE) | 2023-02-08 | — | — | EP | disclosed |