Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.34 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.34 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30179158 | 0.84 | GRIN2B (0.38) | PRMT5KDRENPP2PARP1SMN1; SMN2 | |
| SCHEMBL23580367 | 0.81 | NAMPT (0.47) | GRM5 | |
| SCHEMBL30178737 | 0.81 | NAMPT (0.47) | GRM5 | |
| SCHEMBL25601647 | 0.80 | PBRM1 (0.33) | HTR1DHTR1BPARP1 | |
| SCHEMBL749352 | 0.70 | GRM5 (0.54) | LNPEPGRM5PRMT1KDM4EALDH1A1 | |
| SCHEMBL30178864 | 0.69 | QDPR (0.45) | KDM4EALDH1A1MAPTHTR1DHTR1B | |
| SCHEMBL24837709 | 0.69 | QDPR (0.45) | KDM4EALDH1A1MAPTHTR1DHTR1B | |
| SCHEMBL22551243 | 0.69 | LNPEP (0.49) | LNPEPGRM5PRMT1MAPTENPP2 | |
| SCHEMBL31131400 | 0.69 | LNPEP (0.49) | LNPEPGRM5PRMT1ALDH1A1MAPT | |
| SCHEMBL25929764 | 0.69 | LNPEP (0.49) | LNPEPGRM5PRMT1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239645-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023278402-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |