Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 5/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.35 |
| ▸ | TRPC7 | Q9HCX4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30178559 | 0.84 | LNPEP (0.40) | ENPP2SMN1; SMN2PARP1KDRPRMT5 | |
| SCHEMBL23580367 | 0.76 | NAMPT (0.47) | JAK1 | |
| SCHEMBL30178737 | 0.76 | NAMPT (0.47) | JAK1 | |
| SCHEMBL25624409 | 0.74 | SMN1; SMN2 (0.38) | GRIN2BENPP2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL22776672 | 0.74 | SMARCA2 (0.45) | SMN1; SMN2JAK2CYP2C19 | |
| SCHEMBL30178663 | 0.71 | TMEM97 (0.36) | GRIN2BENPP2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL25602819 | 0.71 | TMEM97 (0.36) | GRIN2BENPP2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL30179045 | 0.71 | TMEM97 (0.36) | GRIN2BENPP2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL30552545 | 0.71 | PARP1 (0.44) | PARP1KDR | |
| SCHEMBL27040297 | 0.71 | PARP1 (0.44) | PARP1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239645-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023278402-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |