Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | SUV39H2 | Q9H5I1 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24847131 | 1.00 | LMNA (0.49) | LMNASMPD3TLR9TP53BACE1 | |
| SCHEMBL30179902 | 0.86 | BACE1 (0.45) | LMNASMPD3TLR9BACE1SUV39H2 | |
| SCHEMBL24847590 | 0.86 | BACE1 (0.45) | LMNASMPD3TLR9BACE1SUV39H2 | |
| SCHEMBL20139012 | 0.81 | LMNA (0.48) | LMNATP53ALDH1A1MAPT | |
| SCHEMBL14852278 | 0.81 | BACE1 (0.55) | LMNASMPD3TLR9TP53BACE1 | |
| SCHEMBL29886110 | 0.81 | SUV39H2 (0.50) | LMNASMPD3TLR9SUV39H2ALDH1A1 | |
| SCHEMBL23216662 | 0.81 | SUV39H2 (0.50) | LMNASMPD3TLR9SUV39H2ALDH1A1 | |
| SCHEMBL17310135 | 0.79 | GPR119 (0.48) | LMNASMPD3TLR9TP53BACE1 | |
| SCHEMBL2365831 | 0.78 | LMNA (0.50) | LMNAALDH1A1MAPTGPR119SMARCA2 | |
| SCHEMBL28704626 | 0.78 | LMNA (0.50) | LMNATP53BACE1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278759-A1 | MK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |